Transdermal Drug Delivery System (TDDS)
The transdermal drug delivery system can deliver the drugs through the skin portal to systemic circulation at a predetermined rate and maintain clinically the effective concentration over a prolonged period of time.
Advantages of Transdermal Drug Delivery System
- Reduces dosing frequency and enhancement of patient compliance.
- It provides the suitability of self-medication.
- Avoid the first-pass effect.
- A long duration of action.
- Ease of termination of drug action, if necessary.
- No interference with gastric and intestinal fluids.
- It allows effective use of drugs with short biological half-life.
Disadvantages of Transdermal Drug Delivery System
- It may cause of skin irritation.
- It requires a high drug load.
- Unsuitable if the drug dose is large.
- Poor diffusion of large molecules.
- Absorption efficiency varies with different sites of the skin.
Related:
Classification of Dosage Forms
